In 2010 alone, in excess of fifty peptide drugs that generated annual sales of over $1 billion each were marketed. Their ability to deal with cancers, tumors, and metabolic diseases is likely to make these drugs a successful commercial venture.
Currently, scientists are trying to find out if these drugs have ability to function as contraceptives, antimicrobials, and vaccines. After peptide drug discovery (http://cmdbioscience.com), scientists are busy in the labs trying to optimize it and lower its degradability. There are host of sources of peptides; they are readily available in multicellular and unicellular organisms. Additionally, they can be acquired from chemical libraries and recombinant. They provide a greater chemical diversity than other classes of biological molecules.
Read To :
The Values Offered By Regular IT Auditing
Due to their easy degradation, peptides are administered through injections. Since they occur naturally, peptides are safer than artificial medication. They have a higher selectivity, efficacy, and specificity. Their bioactivities are important for drug discovery and include amino acids and coordination of major physiological processes.Therefore, they can neutralize complications at a faster rate than synthetic medications. After peptides undergo the degradation process, they produce proteinogenic amino acids. Unlike artificial medications that produce toxic metabolites, these drugs are safe. The toxic metabolites cause series side effects and can sometimes cause other complications such as ulcers. The safety nature of peptides might have facilitated its popularity that is being witnessed. Its short half-life property has some health advantages since the human body does not have to deal with metabolites for a long time. In contrast to antibodies and bigger proteins, peptides have ability to penetrate deep into the tissue at a fast rate.
Additionally, their manufacturing cost is significantly lower than recombinant antibodies and proteins. Due to their high stability and activity, these drugs can be put in storage at a room temperature. Most of them are acquired from polypeptides or protein and they can intermingle with membrane proteins. Activation or deactivation of some target receptors is possible when small amount of peptides are utilized. Currently, very few peptides antagonists that promote ligand-receptor reactions are available on the market.
The health care market has experienced a significant increase in the number of peptides that are launched each year. Most of them are peptide hormones and derivatives that promote hormone action. The increase in popularity of these drugs began back in 2010. However, some of medications that were launched in 2010 have been withdrawn. Currently, scientists are conducting a series of clinical trials to determine the efficacy of peptides.
Those under trials are believed to have properties of healing several infectious disease and oncology. They are introduced into the body through intravenous and subcutaneous techniques. The major challenge that is hindering commercialization of peptides is its administration procedure and easy degradation. Researchers are trying to come with solutions that allow administration of peptides in a form that is not easily degraded in the digestive system.
The collaboration of stakeholders in the health industry and scientist is likely to bear fruits. Stabilization of peptides through optimization is a strategy that scientists are currently using. The first clinical trial involved administering the drug, which was encapsulated with silica particles into the alimentary canal of animals. The outer coat lowers the rate of degradation and promotes circulation of the drug in the body longer.
Source : By Daniel West, About the Author: When you are looking for the facts about peptide drug discovery (http://cmdbioscience.com), come to our web pages online here today. More details are available at http://cmdbioscience.com now.
EmoticonEmoticon